Nicotinamide Riboside Benefits and Side Effects

Senior hispanic man working on a white backgroundNicotinamide Riboside is said to repair functioning of the mitochondria which power energy generation in every cell in our bodies.

This is supposed to “turn back the clock” and make us younger, and repair many (not all) of the ravages of aging.

There have been several research studies  with NR and NMN that do show great promise, but also leave some questions to be answered by other studies that are currently underway

In this article we examine the research to date on Nicotinamide Riboside.


NR has been shown to increase NAD+ levels in humans.

This results  in speculation that NR might be useful in treating many age related health conditions such as:

  • alzheimers
  • parkinsons
  • metabolic syndrome
  • erectile dysfunction
  • rheumatoid arthritis
  • depression
  • thyroid
  • prostate cancer
  • hearing loss
  • acne
  • appetite suppression

Testing is currently underway to evaluate Nicotinamide Riboside  for treating many of these symptoms.

Research studies  with mice have demonstrated that supplementation with NR:

  • Improves cognition in mice with Alzheimers (32) 2013
  • Lowered cholesterol, improved hepatic inflammation in tumors (33) 2015

To date the only completed testing with human subjects for treatment of specific conditions is:

  • Protects against hearing loss caused by noise exposure (34) 2014

Many studies are currently ongoing such as an obesity study underway by  the Novo Nordisk Foundation Center for Basic Metabolic Research.

[box]Conclusion: Nicotinamid Riboside has proven effective in treating several degenerative conditions. Much more testing is needed and currently underway. [/box]


Decreased NAD+ levels are implicated in many age related disease and disabilities.

NR does raise NAD+ levels in human tests lasting 1 week. Long term testing is not yet complete.

NR has been shown to improve or protect against some age related problems, and shows potential for much more.

In addition to protecting various organs such as liver and kidney, heart, lungs, and neuro-protection, NR is marketed as a potential anti-aging therapy. It may yet prove to be of some benefit in slowing some aspects of the aging process, but as yet there is no definitive proof.

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