Besides storing fat, the body has several methods to survive periods of food shortage and starvation.
One of them is called adaptive thermogenesis, sometimes referred to as “starvation mode.”
It involves a reduction in the amount of calories your body burns, resulting in slower weight loss and faster weight regain.
It is defined as a decrease in resting energy expenditure during calorie restriction, beyond what can be explained by reduced mass of muscles, organs and fat.
Although adaptive thermogenesis is well-known, how it works remains unclear.
German researchers set out to investigate the causes and dynamics of adaptive thermogenesis (starvation mode).
They wanted to find out how body composition affects adaptive thermogenesis, whether it causes changes in hormones, and what effect it has on weight regain.
Muller et al. Metabolic Adaptation to Caloric Restriction and Subsequent Re-feeding: The Minnesota Starvation Experiment Revisited. American Journal of Clinical Nutrition 2015.
The article describes the results of two related studies from Christian Albrechts University, in Germany.
This 6-week intervention study included 32 healthy, non-obese men, between 20 and 37 years of age.
Before the intervention started, participants spent 10 weeks at the university’s metabolic ward where their energy needs were calculated.
The intervention was divided into three parts:
- Overfeeding: For one week, the participants were overfed so that their calorie intake exceeded their energy needs by 50%.
- Calorie restriction: For three weeks, the participants were semi-starved so that their calorie intake was 50% lower than their energy needs.
- Re-feeding: For two weeks, the participants were again overfed so that their calorie intake exceeded their needs by 50%.
All participants spent every day, from 8 AM to 6 PM, at the university’s metabolic ward, where they were measured and monitored.
Dietary intake was strictly controlled. All foods were weighed and all meals supervised.
Additionally, participants were encouraged to avoid any physical activity and to remain sedentary.
Compliance was ensured by using continuous 24-h glucose monitors, pedometers and dietary records.
Body composition was measured using various techniques. These included quantitative magnetic resonance and whole-body MRI.
The levels of various hormones and other relevant body processes were also analyzed throughout the study.
A smaller follow-up study was done 1.5 years later than the original study.
This study included only eight of the participants that took part in the first study.
Its purpose was to estimate the effects of short-term calorie restriction on adaptive thermogenesis.
Additionally, it examined whether the results of the earlier study were reproducible.
It was divided into two parts:
- Overfeeding: Participants were overfed for one week.
- Calorie restriction: Participants were calorie restricted for one week.
Otherwise, the methods were similar to the first study.
This chart below shows the changes in body composition over the course of the study (click to enlarge):
The top graph shows change in body weight, the middle graph shows a change in fat mass, and the bottom graph shows nitrogen balance, which indicates changes in lean mass (mostly muscles and organs).
After three weeks of calorie restriction, body weight decreased by 6 kg (13.2 lbs – 7.5%) and resting energy expenditure dropped by 266 calories per day, on average.
Adaptive thermogenesis was detected in 60% of participants in the early stages of calorie restriction. It became significant on the third day.
It was partly responsible for the decrease in energy expenditure, accounting for 108 calories/day.
Of these 108 calories per day, 36 were explained by changes in the composition of fat-free mass, leaving 72 calories for “true” adaptive thermogenesis.
Factors that were associated with adaptive thermogenesis included reduced insulin levels, heart rate, kidney function and body fluid balance. Increased formation of glucose in the liver also appeared to play a role.
Adaptive thermogenesis was not associated with changes in sympathetic nervous system activity, total body fat, belly fat, liver fat, organ mass, nitrogen and sodium balances.
It was also not linked to hormonal changes, such as in leptin, ghrelin, adiponectin and thyroid hormone levels (T3).
Lastly, adaptive thermogenesis appears to have no long-term effects on weight or fat regain after short-term calorie restriction. The effect was reversed within two weeks of re-feeding.
Here you can see how energy expenditure changes from adaptive thermogenesis developed during the course of the study:
As you can see, the increase during the re-feeding phase completely reversed the decrease seen during the calorie restriction phase.
Several other parameters changed significantly during 3 weeks of severe calorie restriction:
- Fat mass: Decreased by 114 grams per day.
- Lean mass: Decreased by 159 grams per day (muscles and organs combined, see below).
- Muscle mass: Decreased by 5%.
- Liver mass: Decreased by 13%.
- Kidney mass: Decreased by 8%.
- Heart rate: Went down by 14%.
- Blood pressure: Went down by 7%.
- Creatinine clearance: Went down by 12%.
- Energy cost of walking: Decreased by 22%.
- Sympathetic nervous system activity: Decreased by 38%.
- Leptin levels: Decreased by 44%.
- Insulin levels: Decreased by 54%.
- Adiponectin levels: Decreased by 49%.
- Triiodothyronine (T3): Decreased by 39%.
- Testosterone: Decreased by 11%.
The main conclusions of the study were as follows:
- Adaptive thermogenesis is modest and kicks in during the early stages of starvation, shortly after calorie restriction starts. It is maintained as long as you keep restricting calories.
- Adaptive thermogenesis appears to have no long-term effects on weight or fat regain after short-term calorie restriction.
- Adaptive thermogenesis was partially explained by reductions in heart rate and kidney function, and increased formation of glucose in the liver.
- In early calorie restriction, adaptive thermogenesis is also associated with a drop in insulin levels.
The study has no apparent limitations. It was tightly controlled and had highly significant results.
However, since the participants were limited to healthy, sedentary, non-obese men, the results may not be generalized to all people.
For example, it is possible that the dynamics of of adaptive thermogenesis are vastly different in people with obesity.
What Do Other Studies Say?
In general, adaptive thermogenesis (AT) is considered to be an automatic response to food shortage.
In the Minnesota Starvation Experiment from 1950, resting energy expenditure declined by 39% (600 calories/day). About 35% of this decline was not caused by changes in body composition, which indicates that AT also played a role (4).
Although the current study showed reductions in both leptin and T3, it did not support a causal relationship between AT and changes in these hormones.
This effect has been referred to as the “fat overshooting” phenomenon (7).
According to the current study, this effect is reversed within 2 weeks of re-feeding.
Summary and Real-Life Application
In short, adaptive thermogenesis (AT) is one of the main reasons your body starts burning fewer calories when you lose weight.
It is a part of the reason why weight loss tends to slow down over time, and is often referred to as “starvation mode.”
In the current study, significant adaptive thermogenesis was detected as early as on the third day of calorie restriction.
Unfortunately, there is no known way to completely prevent this from happening.
Additionally, by exercising more and staying active throughout the day, you can negate some of the reduction in energy expenditure.