Archive | May, 2017

Methylene Blue May Protect Against Skin Aging

Methylene blue appears to slow and reverse aspects of the aging process in human skin Described as “the first fully synthetic drug used in medicine”, methylene blue is a common and inexpensive chemical used to treat several conditions and is also a potent staining agent. Prior work has demonstrated it has significant potential to treat […]

Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system: a randomised, placebo-controlled, double-blinded cross-over trial

Chlorogenic acids (CGA) are one of the most common substances in coffee beans. CGA was a huge fad back in 2012 when Dr Oz featured Green Coffee Beans on his show for their supposed weight loss benefits. He actually carried out a study with 100 women from his studio audience, with half getting a placebo […]

Mitochondrial transplantation: From animal models to clinical use in humans

1. Introduction The importance of the mitochondrion in the maintenance and preservation of cellular homeostasis and function is well established and there is a sufficient body of evidence to show that mitochondrial injury or loss of function is deleterious (Durhuus et al., 2015). The mechanisms leading to mitochondrial dysfunction are varied and include genetic changes […]

Sulforaphane a powerful tool to fight cancer, aging, and other inflammatory health issues

Sulforaphane has been shown to be an effective antioxidant, antimicrobial, anticancer, anti-inflammatory, anti-aging, neuroprotective, and anti-diabetic (R). It also protects against cardiovascular and neurodegenerative diseases (R). Many test-tube and animal studies have found sulforaphane to be particularly helpful for suppressing cancer development by inhibiting enzymes that are involved in cancer and tumor growth (R, R, R). According […]

NMNAT: It’s an NAD+ synthase, chaperone, AND neuroprotector

Nicotinamide mononucleotide adenylyl transferases (NMNATs) are a family of highly conserved proteins indispensable for cellular homeostasis. NMNATs are classically known for their enzymatic function of catalyzing NAD+ synthesis, but also have gained a reputation as essential neuronal maintenance factors. NMNAT deficiency has been associated with various human diseases with pronounced consequences on neural tissues, underscoring […]

Cruciferous Vegetable Intake Is Inversely Associated with Lung Cancer Risk among Current Nonsmoking Men in the Japan Public Health Center Study

Abstract Background: Cruciferous vegetables, a rich source of isothiocyanates, have been reported to lower the risk of several types of cancer, including lung cancer. However, evidence from prospective observations of populations with a relatively high intake of cruciferous vegetables is sparse. Objective: We investigated the association between cruciferous vegetable intake and lung cancer risk in […]

Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease.

Study published here Highlights   NMN improved behavioral measures of cognitive impairments in AD-Tg mice.   NMN decreased β-amyloid production, amyloid plaque burden, synaptic loss, and inflammatory responses in AD-Tg mice.   NMN reduced JNK activation in AD-Tg mice.   NMN regulated the expression of APP cleavage secretase in AD-Tg mice. Abstract Amyloid-β (Aβ) oligomers […]